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Disulfiram inhibits activating transcription factor/cyclic AMP-responsive element binding protein and human melanoma growth in a metal-dependent manner in vitro, in mice and in a patient with metastatic disease

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Since mutant ChaC1-knock-in mice have been examined only in limited situations, it remains ambiguous whether a deficiency of CHAC 1 activity affects phenotypic properties under pathological conditions such as ER stress, oxidative stress, and ferroptosis

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