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Key Research Highlights: Largest MK-677 trial: 563 participants, 12 months, 25 mg/day IGF-1 elevated 73% at 12 months (robust pharmacological effect confirmed) No slowing of Alzheimerβs progression on any cognitive or functional measure Critical null result in a well-powered, adequately dosed trial MK-677 Body Composition Research in Obese Subjects A two-month study in obese subjects found that MK-677 increased GH secretion, fat-free mass, and energy expenditure
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B12 injections β no weight-loss edge Studies comparing injected vs oral B12 during calorie-restricted diets found no difference in objective weight or body-composition outcomes, though the injection group sometimes reported more subjective energy
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