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Metabolic characteristics include: Plasma half-life of 11-12 minutes after either intravenous or subcutaneous administration Very rapid clearance rates of 2.4-2.8 L/min in adult subjects Degradation primarily through peptidase enzymes in plasma and tissues No accumulation observed even with repeated daily dosing The extremely short half-life reflects the peptide’s susceptibility to proteolytic cleavage at multiple sites along its amino acid sequence
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Supernatant was analyzed with HPLC system combined with the Sciex QTRAP LC/MS/MS system equipped with TurboIonSprayTM source
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