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Recent findings intriguingly suggest that OPTN plays a role in the senescence of renal tubular epithelial cells when exposed to elevated glucose levels (Chen et al., 2018)

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Erythropoietin binds to the erythropoietin receptor on developing erythroblasts, which triggers a signaling cascade mediated through the non-receptor tyrosine kinase (phosphorylates tyrosine residues on other proteins), Janus-activated kinase-2 (JAK2), resulting in the differentiation and survival (by upregulating anti-apoptotic genes, such as BcL-xL) of erythroid progenitors