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The concern: the same pathways that promote healing can also be hijacked by cancer cells
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At present, the FDA has approved a variety of monoclonal antibodies targeting angiogenesis signaling pathways (such as bevacizumab and cetuximab, etc.) and tyrosine kinase inhibitors (sorafenib and lenvatinib, etc.) for the treatment of tumors, and many preclinical studies have demonstrated their significant anti-tumorigenesis effects (223)
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