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The anxiety model of ovariectomized rats treated with BBR (100 mg/kg) for 4 weeks show significant improvement in anxious behavior and increased levels of the bacterial community metabolite equol (which has potential estrogen-like effects)

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Loss of these metabolites, coupled with excessive activation of innate immune pathways (e.g., TLR2–MyD88–NF‑κB), fosters skin inflammation, metabolic disturbances, and oxidative stress, ultimately disrupting skin immune homeostasis

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