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TrxR1 is the most abundant member of the TrxR family and is expressed in the cytosol ( TrxR1 is a selenoprotein (Tamura and Stadtman, 1996), and its activity relies on the efficient incorporation of selenocysteine (Sec, U) in response to the UGA codon at position 550
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The global impact of diabetes is closely connected to the development of early insulin resistance, which stems from impaired signaling at the insulin receptor (INSR)
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