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These findings underscore the developmental importance of early microbial signals in shaping neural circuits and behavior, processes modulated by molecules such as reelin, which controls dendritic growth and synaptic receptor function in post-natal entorhinal cortex neurons (Hamad et al., 2021b,a, 2024b,a

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In cancer patients, a detrimental effect of vitamin D supplementation may be associated with defective VDR signaling, according to data from preclinical studies: VDR deficiency could lead to the loss of vitamin D's beneficial effects and possibly the emergence of harmful effects, such as the upregulation of tumor angiogenesis and suppression of anti-tumor immunity (73–77)