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effect and kidney) observed in kidneys only CD-1 mice (bone marrow 220 mg/m 3 - ve [118] cytogenetics for 6 h, 5 days/week for 12 months CD rats (bone marrow 220 mg/m 3 - ve [118] cytogenetics for 6 h, 5 days/week for 12 months Rats (male and female) 0, 100, or 300 - ve [178] (bone marrow cytogenetics) mg/m 3 for 6 months ICR mice (bone marrow One-half LD 50 - ve [26] cytogenetics one-sixth LD 50 x 5 days Male ddY mice (bone 0-200 mg/kg or - ve [196] marrow micronucleus 0-100 mg/kg x 4 assay) by gavage Chinese hamster 120 or 400 mg/m 3 + ve [77] (bone marrow (30 or 100 ppm) cytogenetics) 6 h/day, 5 days/week for 6 weeks Table 9 (contd)

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Biological Functions of ALA ALA is the only known antioxidant with both water and lipid solubility, known as the “universal antioxidant”