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It occurs in many tissues outside the brain, and its concentrations fluctuate with a circadian rhythm, which further complicates interpretation

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Among the most closely watched were the first oral glucagon-like peptide-1 (GLP-1) receptor agonist for obesity without food or water restrictions, the first all-oral frontline regimen for acute myeloid leukemia (AML), the first therapy FDA-approved for focal segmental glomerulosclerosis (FSGS), the first gene therapy for hearing loss tied to OTOF mutations, and the first new treatment for high-risk non–muscle-invasive bladder cancer (NMIBC) in more than 30 years