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Highlights Glutathione (GSH) is the most abundant endogenous antioxidant in brain Oxidative stress is a prominent feature of Alzheimer disease and MCI brain Elevation of GSH in vivo protects brain against AD-relevant Abeta(1β42) Elevation of GSH in brain induces several protective pathways Acknowledgements This work was supported in part by NIH grants to D.A.B
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275 Rather than functioning as isolated linear cascades, oncogenic pathways form dynamic, self-stabilizing systems capable of re-establishing essential survival outputs under therapeutic pressure
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