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Metabolism & Elimination The metabolic fate of Epithalon has been partially characterized in animal models, revealing rapid clearance kinetics[16]: Plasma half-life under 1 hour in most animal studies Rapid enzymatic degradation likely through peptidase activity Metabolic breakdown products not fully characterized Clearance patterns vary significantly between administration routes A notable pharmacokinetic paradox exists: despite rapid plasma elimination, biological effects persist for days to weeks after administration, suggesting either active metabolite formation, tissue retention, or persistent activation of cellular signaling cascades

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doi: 10.3390/ph18020202

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