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Cell growth was completely inhibited at 10-30 µg/ml but was not affected at a concentration 0.17 mg/kg bw per day produced a dose-dependent increase in serum estradiol concentration, and all doses produced a dose-dependent decrease in serum progesterone concentration on test day 90, which correlated with ovarian atrophy and lack of corpora lutea

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The samples were stored at −80 °C until they were sent for transcriptomic analysis