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A nanocatalytic sensitizer that co-delivers Vc–Fe(II), OTUB2 siRNA and a MALAT1 antisense oligonucleotide, combined with the anti-hematogenous metastasis peptide AHP-DRI-12, overcomes AZD9291 resistance, re-engages ferroptotic lipid peroxidation, and markedly suppresses lung metastasis in orthotopic and patient-derived xenograft models [175]
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