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The C596-U597 cysteine pair is thought to bridge these oxidant binding sites acting as a tethered mobile mediator between the C154-C159 disulfide, the disulfide of the SmTrx substrate (C34-C37) and the C28-C31 disulfide adjacent to the GSSG binding site
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E 2( t ) itself is a piecewise linear function found by applying the spline function in Matlab to the data in Panel A of Figure 2 for estradiol as a function of day of the cycle for the average woman
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