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Elevated reactive oxygen species (ROS) in the TME can enhance NADPH production by secreting inflammatory cytokines, stabilizing hypoxia-inducible factor (HIF) and activating the AMPK signaling pathway, thus promoting tumor metastasis and angiogenesis [266]
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Competing interests The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest
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