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Animal trials and initial human clinical data form the basis for current research, generating doubts about their relevance when applied to large human clinical trials
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first, they convert to acetyl coenzyme A in the presence of ATP-citrate lyase (ACL), which is the first step in endogenous fatty acid synthesis (139), and then, acetyl-CoA carboxylase (ACC) acts to produce malonyl-CoA, thereby initiating DNL
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