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There are various mutations related to PD, i.e., α-synuclein, LRRK2, PINK1, Parkin, DJ-1, VPS35, GBA1, and the loss of the dopaminergic neuron potential (Zeng et al., 2018)

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And GLP-1 agonists change how the body processes alcohol, leading to increased sensitivity and faster intoxication in many users