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Such epigenetic reprogram results in a reversible cell state switching which is AZD1775 specific because it is not observed in L-asparaginase, cytarabine, or doxorubicin treatment
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This cycle primarily involves γ-glutamyl peptidase (GGT), the only enzyme that catabolizes GSH, GSSG, and GS-X, as well as dipeptidyl peptidase (DP)
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