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A comprehensive literature search was performed across PubMed, Scopus, and Web of Science databases up to May 2025 using keywords such as “hesperidin,” “neuroprotection,” “epigenetics,” “oxidative stress,” “Alzheimer’s disease,” and “Parkinson’s disease.” Relevant experimental and clinical studies were selected based on scientific relevance, methodological rigor, and novelty

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The mentioned data suggest that further research is needed to identify specific patterns that may help to segregate pathways of lung and systemic injury or direct and indirect ARDS, respectively [14]