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The drug Ononin has been shown to exert chondroprotective effects in an IL-1β-induced chondrocyte inflammation model by inhibiting the expression of ECM-degrading enzymes such as MMP-13 and reducing type II collagen degradation, achieved through the downregulation of the MAPK signaling pathways (105)
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Gedik N, Krüger M, Thielmann M, Kottenberg E, Skyschally A, Frey UH, Cario E, Peters J, Jakob H, Heusch G, Kleinbongard P
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