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Extended absorption of liothyronine from poly-zinc-liothyronine (PZL): results from a phase 1, double-blind, randomized, and controlled study in humans

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Interestingly, based on study evidence, sex differences also critically modulate oxidative stress responses and neurodegeneration susceptibility through distinct molecular mechanisms: Females exhibit superior antioxidant capacity via estrogen‐mediated Nrf2 activation, enhancing GSH synthesis and ROS clearance, while males demonstrate heightened vulnerability to oxidative DNA/lipid damage (e.g., elevated 8‐oxoG) due to androgen‐driven mitochondrial ROS overproduction [155]