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This can result in oxidative stress and neurotoxicity, further exacerbating neuronal damage [370,371,372]
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While lysosomal mTORC1 could detect extracellular or autophagy-derived amino acids in the lysosomal lumen, Golgi-localized mTORC1 could be regulated by amino acids trafficked back in a retrograde manner from the endosomal system or brought into the Golgi lumen by Golgi-localized amino acid transporters
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