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While targeting glutamine pathways—particularly GLS1 and α-KG metabolism—presents promising antifibrotic potential, the cell type-specific and compensatory mechanisms highlight the need for precise therapeutic strategies to effectively harness glutamine-targeted interventions in IPF (Fig
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Discovery of multi-receptor agonists for the GIPR and GLP-1R The multifactorial nature of physiological control of metabolism and body weight, coupled with the demonstration that gastric bypass procedures increase secretion of GLP-1 and several other gut-derived hormones, suggested that engineering medicines combining GLP-1R activity with other hormonal stimuli might offer superior clinical outcomes
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