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Alpha-Ketoglutarate (aKG) supplementation significantly reversed the decrease in the cFLIP level induced by glutaminolysis inhibition and rescued PDAC cells from TRAIL/Gln deprivation-induced apoptosis
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However, while the typical response to fasting in normal mice is to increase fatty acids and ketones, leptin treated mice have reduced fatty acids in the fed state and are further depleted upon fasting, which, therefore, may contribute to the blood glucose lowering effect of leptin [62], [131]
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