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Taken together, these findings support the emerging role of lipid metabolism regulators, particularly PCSK9, as modulators of therapeutic response, with potential implications for overcoming drug resistance and optimizing combination treatment strategies in oncology

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For example, superoxide dismutase (SOD, a metalloprotein that catalyses the dismutation of superoxide radical into hydrogen peroxide and molecular oxygen), catalase (CAT, a hemoprotein deputed to the conversion of peroxides into water and oxygen), peroxiredoxins, glutathione peroxidases (GPXs, a family of selenoproteins that exploit GSH as electron donor to allow the reduction of hydrogen peroxide to alcohol and water), glutathione reductase (GR) and the thioredoxin system are among the enzymatic components of the endogenous antioxidant system [5]