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Inflammation is described as a complex physiologic defense mechanism consisting of local changes in hemodinamy, increase in microvascular permeability and a series of intracellular reactions [4]

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created a machine-learning model that predicts treatment outcomes for etanercept and tofacitinib by analyzing the longitudinal serotype profiles of 92 inflammatory markers and 65 cardiovascular disease-related proteins measured at baseline and four weeks into treatment [146]