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Frontiers | The reprotoxic adverse side effects of neurogenic and neuroprotective drugs: current use of human organoid modeling as a potential alternative to preclinical models

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There was a significant decrease from TP1 to TP2 ( β = –2.54, SE = 0.70, P = 0.005) and a trend toward a significant decrease from TP0 to TP2 ( β = –1.41, SE = 0.74, P = 0.069) in the drug-neutral 400–1000 ms LPP and a trend toward a significant decrease from TP1 to TP2 in the drug-neutral 400–2000 ms LPP ( β = −2.33, SE = 0.95, P = 0.069), whereas no main effect of time was detected in the drug-neutral 1000–2000 ms LPP