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Interestingly the two individuals with active CD and high GPx1 expression had H 2 O 2 -induced cytotoxicity within the healthy control range (i.e., 3.5% and 4.4%)
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Both nitration and dityrosine formation are enhanced in disease states marked by iron overload, increased NO production, or chronic inflammation, as observed in β-thalassemia and sickle cell disease [108]
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