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Among the promoters that were differentially methylated, we must highlight RUFY1 and S100A1 in the CMAIE group, observing that RUFY1 was hypomethylated, and previous studies have demonstrated changes in DNA methylation of this gene in children sensitized to airborne allergens ( S100A1 was found to be hypermethylated in our sample, and similar studies have also identified hypermethylated regions in this gene in adolescents with multi-food allergies and in children with atopic dermatitis ( Moreover, DMRs in promoters and genes have been identified in patients with IgE-mediated allergy after a cow’s milk restriction diet
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