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The MAPK cascade pathway is highly correlated with abiotic stresses such as high temperature and drought

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She et al (110) have found that malonyl-coenzyme A can induce the volt-dependent anion channel 2 malonylation in septic mice, which changes the structure of the N-terminal of the channel, causing mitochondrial dysfunction, increasing mitochondrial ROS levels, leading to ferroptosis and aggravating SIC (Fig