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most intranasal research Mice – Used in ischemia-reperfusion, pain, and longevity studies Dogs – Referenced in early pharmacokinetic and sleep characterization research Cats – Used in early sleep staging studies where REM effects dominated Cell cultures – Hippocampal and cerebellar neuron preparations for receptor interaction studies Research Limitations & Regulatory Status Critical Gaps in Current Evidence Despite nearly 50 years of research, DSIP faces fundamental unresolved questions that significantly limit the interpretability of published findings and preclude clinical application