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By adulthood (postnatal day 196), these animals exhibited significantly increased PIN incidence, higher Gleason scores, and elevated serum PSA levels, illustrating a clear “developmental-senescence” continuum of potential carcinogenic susceptibility (Wang et al., 2017)
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Further modifications, including solubility-enhancing groups, led to UAMC-3203, which demonstrated superior potency, stability, and solubility, with no toxicity in mouse models (Devisscher et al., 2018)
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