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FIGURE 2 5.2 Targeting signaling pathways 5.2.1 Inhibition of NF-κB and p38 MAPK pathways Research indicates that targeting the Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells (NF-κB) and p38 Mitogen-Activated Protein Kinase (p38 MAPK) signaling pathways significantly diminishes the release of pro-inflammatory cytokines IL-1β and TNF-α

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