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IGF-I acts predominantly via the IGF-I receptor (IGF-IR), a transmembrane protein consisting of two extracellular ฮฑ-subunits, which contain the IGF-I binding site, and two transmembrane ฮฒ-subunits that have a cluster of three tyrosine residues, which undergo phosphorylation and activation upon IGF-I binding to mediate canonical signaling pathways necessary for cell survival and growth
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Tea is a rich source of phytochemicals called โnon-nutrientโ antioxidants, specifically polyphenols known as tea flavonoids
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