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Protein-thiol oxidation and cell death: Regulatory role of glutaredoxins
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Variants:1 Bloom + 1 Sleep
HDAC9 mediates the deacetylation and ubiquitination of the transcription factor Sp1 through its histone deacetylase activity modification, leading to Sp1 degradation, which inhibits the transcriptional expression of GPx4, a key factor in resistance to ferroptosis, and ultimately drives neuronal ferroptosis in models of cerebral ischemia
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