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Further, this study provides new evidence that mitochondrial superoxide production may be elevated in certain brain regions and that a neuroinflammatory process may promote oxidative stress and damage in affected cells

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Animal studies utilizing acute stress models have shown that in mice stress-induced BBB permeability reduces the pyridostigmine dose required to inhibit brain acetylcholinesterase by 50% to less than 1/100th of the usual dose used (Friedman et al, 1996)