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In this way, with the onset of endothelial cell activity, certain types of metalloproteases are secreted from the tip cells and decompose the basement membrane in the mentioned region [12]
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During the early stages of nervous system development, NSCs continuously proliferate, providing a sufficient cellular source for neural network formation, and gradually differentiate into various types of neural cells, such as neurons, astrocytes, and oligodendrocytes, thereby establishing a complex and precisely regulated neural network[351]
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