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Colonic diverticulosis, a common condition in older adults (affecting over 50% of people by 60 years of age), is distinct from appendiceal diverticulosis, which is extremely rare (identified in less than 2% of appendectomy specimens) [1, 10]

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Beyond the classical Warburg effect, emerging evidence highlights the pivotal roles of altered lipid metabolism, amino acid utilization, and the metabolic crosstalk within the tumor microenvironment (TME)