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Inhibitors: KU-60019, (S1570, Selleckchem), M3814 (S8586, Selleckchem), AZD6738 (S7693, Selleckchem), Rapamycin (AY-22989, Selleckchem), Mirdametinib (PD0325901, Selleckchem) Stable isotope tracing U87 cells were labeled by culturing in DMEM media lacking glutamine, methionine, and cystine (Cat# 21013024, Thermo Fisher)
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Their mechanisms are complementary rather than identical, which is the rationale researchers cite for combining them — though no human trial has tested the combination
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