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Evidence snapshot: The strongest human evidence comes from a 2-year randomized controlled trial in 65 healthy older adults (Nass et al., 2008, Annals of Internal Medicine) showing sustained GH/IGF-1 increases and preserved fat-free mass, plus an earlier short-term human polysomnography study on sleep (Copinschi et al., 1997, Neuroendocrinology, PMID 9349662)

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In humans, direct ANP infusion at maximal dose increases lipolysis greater than 10-fold (114) and can decreases blood pressure, and increases post-prandial lipid oxidation and energy expenditure (111), suggesting therapeutic benefits of ANP treatment are possible in man