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The researchers thus concluded that such an intervention could be used to complement the treatment of chronic liver damage.16 A fairly recent review published in 2020 affirms that silymarin can be effective as a supportive treatment for liver diseases

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In summary, the role of lactate in macrophages cannot be oversimplified as merely “promoting M2.” It functions more like a “double-edged sword,” with its ultimate effect, whether it favors pro-inflammatory (M1) or anti-inflammatory (M2) phenotypes, being tightly regulated by factors such as concentration, duration, cell origin, and the overall tissue microenvironment [108]