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This guide separates them, explains what the “D-retro-inverso” designation actually specifies at the chemical level, and describes the FOXO4–p53 interaction that motivated the design

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Here’s how it works: The hypothalamus (in the brain) signals the pituitary gland The pituitary gland sends messages to the adrenal glands (above the kidneys) The adrenals release cortisol , your body’s primary stress hormone This system is essential for survival