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PHYSIOLOGY OF EICOSANOID METABOLISM Eicosanoids are centrally involved in a number of metabolic pathways that exhibit diverse roles in inflammation and cellular signaling
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Although separated by anatomical barriers, lamina propria macrophages and brain BAMs are exposed to shared systemic cues, including circulating cytokines, microbial metabolites such as short-chain fatty acids (SCFAs) or lipopolysaccharide, and neuroendocrine signals transmitted via the vagus nerve or hypothalamic-pituitary-adrenal axis ( Thus, rather than functioning as isolated populations, lamina propria macrophages and brain BAMs may participate in a bidirectional, density- and threshold-dependent communication network that echoes quorum sensing principles
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