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This oxidative stress triggers lipid peroxidation, where ROS react with polyunsaturated fatty acids in cell membranes, forming reactive aldehydes such as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) [46,47,48]

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In man serum fasting levels of inorganic sulfate were shown to increase with age and exhibit a circadian rhythm, probably associated with food intake