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An injectable hydrogel for synergistic therapy in colorectal cancer by targeting glutathione: Cell Reports Physical Science

Our mechanistic findings can provide a rational approach for developing cancer treatments through targeting the ASXL1-BRD4 interaction with small molecule inhibitors, because the cancer-specific truncation variants of ASXL1 but not full-length ASXL1 have previously been shown to appreciably interact with BRD4 and induce myeloid malignancies in animal models 6,26,39

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The publication also includes Pal-GHK, a synthetic peptide analog derived from the naturally occurring tripeptide GHK and chemically modified with a palmitoyl group