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Second, the antioxidant response element (ARE) acts as a pivotal modulator of Nrf2-driven SLC7A11 activation, with its relationship to Nrf2 occurring irrespective of p53 involvement (70)
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Interindividual variability is high even when circumventing the gut microbiota with isolated metabolites, with plasma urolithin A-glucuronide levels in healthy adults exhibiting a 49% relative coefficient of variation after a standardized dose of 500 mg of urolithin A (28)
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