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What Causes Black or Tarry Stool?

Direct contact with the gut lining during alcohol exposure provides localized protection exactly where damage occurs

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The TJ is a multi-protein complex that forms a selectively permeable seal between adjacent epithelial cells and demarcates the boundary between apical and basolateral membrane domains.8 The modification of TJ barrier function and paracellular permeability is dynamically regulated by various extracellular stimuli and is closely associated with our healthy and susceptibility disease.1,9 TJ barrier disruption and increased paracellular permeability, followed by permeation of luminal pro-inflammatory molecules, can induce activation of the mucosal immune system, resulting in sustained inflammation and tissue damage