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Without strain, both Rho and ROCK were upregulated in tumor ECs compared to control, and since there was no significant difference between Rho activity in the strained control conditions and the tumor ECs, mechanical factors in the TME may be causing activation of the Rho/ROCK pathway (220)
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These specialized protein complexes, composed of claudin, occludin, and zonulin, among other molecules, form a seal in the paracellular space between adjacent IECs, thereby tightly controlling the passage of ions and solutes (165)
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