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X2 is E the antibody or antigen-binding fragment comprises six complementarity determining regions ( , CDRH2, CDRH3, CDRL1 , CDRL2, and CDRL3, wherein CDRH1 comprises the sequence SYGMS 201 ), CDRH2 comprises the sequence SX1TGSGGX2TYYPDSVKG (SEQ ID NO: 275) wherein Xi i is E or A, CDRH3 comprises the sequence DLLX1RFLEWSHYYGMDV (SEQ ID NO: 272) wherein DRL1 comprises the sequence RSSQSLLHSSGHNFLH (SEQ ID NO: 204), CDRL2 comprises the sequence ETSNRX1X2 (SEQ ID NO: 276) wherein Xi is V or A and X2 is P or S, and CDRL3 comprises the sequence X1QQX2TQX3PX4X5 (SEQ ID NO: 277) wherein Xi is M or Q, X2 is Q or A, X3 is Y or F the antibody or antigen-binding fragment comprises six complementarity determining regions (CDRs): CDRH1 , CDRH2, CDRH3, CDRL1 , CDRL2, and CDRL3, wherein CDRH1 comprises the sequence GFTFX1SY (SEQ ID NO: 278), wherein X is S or T, CDRH2 comprises the sequence TGSGG (SEQ ID NO: 279), CDRH3 comprises the sequence LLX1RFLEWSHYYGMD (SEQ ID NO: 280) wherein Xi is I or V, CDRL1 comprises the sequence of SQSLLHSSGHNF (SEQ ID NO: 281 ), CDRL2 comprises the sequence EX1S wherein Xi is T or V, and CDRL3 comprises the sequence X1X2X3X4X5X6 wherein Xi is Q, R, or A, X2 is T or P, X3 is Q or F, X 4 is Y, F, or G, CDRH1 comprises the sequence the antibody or antigen-binding fragment comprises six complementarity determining regions (CDRs): CDRH1 , CDRH2, CDRH3, CDRL1 , CDRL2, and CDRL3, wherein CDRH1 comprises the sequence GFTFTSSYG (SEQ ID NO: 284), CDRH2 comprises the sequence X1TGSGGX2T (SEQ ID NO: 285) wherein Xi is F or I and X2 is E, T, or A, CDRH3 comprises the sequence ARDLLVRFLEWSHYYGMDV (SEQ ID NO: 286), CDRL1 comprises the sequence QSLLHSSGHNF (SEQ ID NO: 287), CDRL2 comprises the sequence EX1S wherein X is T or V, or the sequence EVSNRVS (SEQ ID NO: 205), and CDRL3 comprises the sequence X1QX2TQX3PX4X5 (SEQ ID NO: 288) wherein Xi is Q or M, X 2 is an anti-pro/latent-myostatin antibody or an antigen-binding portion thereof suitable for carrying out various embodiments of the present disclosure comprises the following six CDRs: a CDRH1 comprising GFTFSSYG (SEQ ID NO: 3)

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doi: 10.1016/S0165-6147(00)89077-X